diff --git a/flashrom.8 b/flashrom.8
index bf671c220..cf07ccf55 100644
--- a/flashrom.8
+++ b/flashrom.8
@@ -573,6 +573,15 @@ The default model is
 and the default interface is
 .BR B .
 .sp
+If there is more than one ft2232_spi-compatible device connected, you can select which one should be used by
+specifying its serial number with the
+.sp
+.B "  flashrom \-p ft2232_spi:serial=number"
+.sp
+syntax where
+.B number
+is the serial number of the device (which can be found for example in the output of lsusb -v).
+.sp
 All models supported by the ft2232_spi driver can configure the SPI clock rate by setting a divisor. The
 expressible divisors are all even numbers between 2 and 2^17 (=131072) resulting in SPI clock frequencies of
 6 MHz down to about 92 Hz for 12 MHz inputs. The default divisor is set to 2, but you can use another one by
diff --git a/ft2232_spi.c b/ft2232_spi.c
index edea1e662..1b8067454 100644
--- a/ft2232_spi.c
+++ b/ft2232_spi.c
@@ -283,7 +283,9 @@ int ft2232_spi_init(void)
 		msg_perr("Unable to select interface: %s\n", ftdic->error_str);
 	}
 
-	f = ftdi_usb_open(ftdic, ft2232_vid, ft2232_type);
+	arg = extract_programmer_param("serial");
+	f = ftdi_usb_open_desc(ftdic, ft2232_vid, ft2232_type, NULL, arg);
+	free(arg);
 
 	if (f < 0 && f != -5) {
 		msg_perr("Unable to open FTDI device: %d (%s)\n", f,